Test

Range

Min

Range

Max

2008

05/29

2008

06/26

2008

07/24

2008

08/22

2008

09/16

2008

10/16

2008

11/13

2008

12/11

2009

01/08

2009

02/05

2009

03/04

2009

04/02

2009

04/30

2009

05/28

2009

06/25

Serum Lambda FLC mg/dL (neph)

0.57

2.63

4.25

4.03

3.30

3.57

2.64

3.14

3.25

4.03

3.31

2.78

2.64

3.04

2.55

2.60

2.63

Serum Kappa FLC mg/dL (neph)

0.33

1.94

1.07

0.88

0.97

1.02

0.91

1.16

1.19

1.84

1.32

1.05

1.10

1.14

0.91

1.01

0.96

Serum K/L Ratio (neph)

0.26

1.65

0.25

0.22

0.29

0.29

0.34

0.37

0.37

0.46

0.40

0.38

0.42

0.38

0.36

0.39

0.36

Serum Lambda LC mg/dL (ifix)

325

725

Serum Kappa LC mg/dL (ifix)

625

1350

Serum K/L Ratio (ifix)

1.47

2.95

Serum IgG mg/dL

750

1550

1260

1450

1360

1040

1180

1130

1170

1260

1350

1160

923

1060

1060

1030

1010

Serum IgA mg/dL

80

450

13

13

12

12

13

15

15

45

25

17

16

18

16

19

26

Serum IgM mg/dL

45

300

15

14

14

12

13

14

20

23

16

16

12

14

12

13

16

Bone marrow plasma cells %

0.1

1.5

Abnormal cohort in marrow %

0

SPEP Monoclonal Peak g/dL

0

1.2

1.1

1.1

1.0

1.0

0.9

1.0

1.0

1.1

1.0

0.9

0.9

0.8

0.9

0.9

Urine Kappa light chains mg/dL

1.5

Urine Lambda light chains mg/dL

2.0

Serum B2M mg/L

0.70

1.80

Serum ESR mm/hr

0

20

CBC PLT platelets K/uL

130

430

235

222

239

212

218

219

224

248

210

213

199

214

189

192

221

CBC WBC white blood count K/uL

3.5

10.8

6.0

5.5

4.7

4.4

5.3

4.4

4.3

5.3

4.6

5.0

4.5

4.2

3.6

4.0

5.6

CBC ANC Neutrophils

1.7

7.0

2.41

1.65

2.09

1.84

2.65

1.95

1.59

2.65

2.11

2.21

1.83

1.93

1.50

1.82

2.99

CBC RBC red blood count M/uL

4.32

5.72

4.23

4.28

4.17

3.99

3.90

3.97

4.19

4.20

4.36

4.28

3.89

4.26

4.01

4.06

3.93

CBC HGB hemoglobin g/dL

13.5

18.0

14.5

14.8

14.3

13.8

13.6

13.8

14.6

14.6

15.3

14.9

13.7

14.7

14.3

14.4

14.0

Chem LDH U/L

140

271

139

162

136

162

135

144

143

130

168

Chem ALT U/L

7.0

55.0

37

40

29

36

30

40

32

87

46

40

44

40

60

35

50

Chem AST U/L

15.0

48.0

25

27

23

29

25

27

24

69

41

33

32

26

35

23

30

Chem Albumin g/dL

3.4

5.0

3.2

4.2

3.4

3.4

3.4

3.4

3.6

3.7

3.7

3.2

3.5

3.5

3.4

Chem BUN mg/dL

7.0

18.0

Chem Calcium mg/dL

8.5

10.3

9.7

10.1

9.7

9.3

9.7

9.6

9.8

10.1

9.9

9.7

9.7

9.5

9.6

10.0

9.6

Chem Creatinine mg/dL

0.6

1.3

1.1

1.0

1.0

1.3

1.0

1.1

0.9

1.0

1.1

1.0

1.0

1.0

0.9

1.0

1.0

Chem Glucose

70

110

82

87

94

83

89

83

83

73

88

84

91

87

84

86

80

MGUS:

SPEP spike present but less than 3 mg/dL, and

Int’l myeloma staging system:

Stage I

B2M < 3.5 & albumin => 3.5

Bone marrow plasma cells less than 10%, and

Stage II

B2M < 3.5 & albumin < 3.5; or 5.5 > B2M => 3.5

No myeloma-related organ, tissue, or bone impairment

Stage III

B2M => 5.5

Test

Range

Min

Range

Max

2006

2/24

2006

6/02

2006

6/26

2006

9/01

2006

12/04

2007

1/11

2007

2/22

2007

3/08

2007

3/28

2007

4/26

2007

6/27

2007

8/02

2007

9/06

2007

10/17

2007

12/26

2008

03/07

2008

04/03

2008

05/01

Serum Lambda FLC mg/dL (neph)

0.57

2.63

3.79

2.35

4.10

4.57

4.46

4.79

4.34

3.71

4.17

3.65

3.63

4.67

5.88

5.70

4.41

Serum Kappa FLC mg/dL (neph)

0.33

1.94

0.17

1.32

0.17

0.20

0.97

0.70

0.72

0.59

0.03

0.17

0.17

0.18

0.14

0.98

0.75

Serum K/L Ratio (neph)

0.26

1.65

0.05

0.56

0.04

0.04

0.22

0.15

0.16

0.16

0.01

0.05

0.05

0.04

0.02

0.17

0.17

Serum Lambda LC mg/dL (ifix)

325

725

3310

3250

2710

3010

2970

3350

3530

3130

3720

Serum Kappa LC mg/dL (ifix)

625

1350

78

72

73

72

72

74

69

62

68

Serum K/L Ratio (ifix)

1.47

2.95

0.02

0.02

0.03

0.02

0.02

0.02

0.02

0.02

0.02

Serum IgG mg/dL

750

1550

1593

1881

2100

1936

2050

2200

2320

2430

2560

2730

3110

2690

3000

2960

2230

1610

Serum IgA mg/dL

80

450

27

20

20

22

22

23

20

19

19

19

16

16

15

12

13

Serum IgM mg/dL

45

300

12

21

20

23

21

19

23

22

22

20

19

19

15

16

13

Bone marrow plasma cells %

0.1

1.5

6.8%

5-10%

Abnormal cohort in marrow %

0

4.0

SPEP Monoclonal Peak g/dL

0

1.2

1.4

1.2

1.57

1.75

1.32

1.70

1.75

1.96

1.90

1.85

2.05

2.70

1.90

1.40

Urine Kappa light chains mg/dL

1.5

0.0

29.1

0.0

0.0

0.0

1.6

0.0

0.0

0.0

0.0

0.0

Urine Lambda light chains mg/dL

2.0

0.0

469.0

0.0

0.0

0.0

0.0

0.0

0.4

0.0

0.0

0.57

Serum B2M mg/L

0.70

1.80

1.51

1.58

1.55

1.57

1.72

1.98

2.03

2.04

1.89

Serum ESR mm/hr

0

20

10

13

21

10

15

15

27

CBC PLT platelets K/uL

130

430

170

190

164

193

227

234

200

184

193

185

180

188

211

303

243

CBC WBC white blood count K/uL

3.5

10.8

4.2

5.1

3.7

4.4

4.9

4.7

5.0

4.3

4.4

5.6

4.2

3.9

5.6

7.7

6.0

CBC RBC red blood count M/uL

4.50

5.70

4.70

4.96

4.49

4.61

4.67

4.66

4.42

4.55

4.60

4.56

4.24

4.44

4.62

4.42

3.95

CBC HGB hemoglobin g/dL

13.5

18.0

14.9

16.0

14.9

15.1

15.6

15.0

14.2

14.9

15.1

15.1

13.9

14.4

15.4

15.1

13.5

Chem LDH U/L

140

271

173

252

324

183

189

233

183

202

190

182

226

188

186

158

131

Chem ALT U/L

7.0

52.0

36

28

25

26

33

22

24

27

22

27

35

20

45

44

32

Chem AST U/L

15.0

37.0

38

33

30

29

38

25

31

28

31

29

41

30

38

32

23

Chem Albumin g/dL

3.4

5.0

4.1

4.5

4.3

4.5

4.3

3.9

4.0

4.5

4.3

4.3

4.4

4.1

4.2

4.5

3.4

3.2

Chem BUN mg/dL

7.0

18.0

23

22

21

24

18

20

21

26

17

22

18

15

Chem Calcium mg/dL

8.5

10.3

9.7

9.3

9.5

9.2

9.9

9.4

10.2

10.0

10.2

10.4

9.7

10.0

10.2

9.9

9.6

Chem Creatinine mg/dL

0.6

1.3

1.1

1.1

1.3

1.1

1.1

1.1

1.1

1.1

1.1

1.2

1.0

1.0

0.9

1.0

1.1

Chem Glucose

70

110

65

61

94

63

73

65

56

97

97

118

80

68

91

89

88

MGUS:

SPEP spike present but less than 3 mg/dL, and

Int’l myeloma staging system:

Stage I

B2M < 3.5 & albumin => 3.5

Bone marrow plasma cells less than 10%, and

Stage II

B2M < 3.5 & albumin < 3.5; or 5.5 > B2M => 3.5

No myeloma-related organ, tissue, or bone impairment

Stage III

B2M => 5.5

Test

Range

Min

Range

Max

2003

4/01

2003

7/02

2003

8/01

2003

8/07

2003

10/09

2003

12/12

2004

1/12

2004

2/16

2004

4/06

2004

5/06

2004

6/08

2004

8/10

2004

11/05

2005

2/07

2005

5/10

2005

8/10

2005

8/19

2005

11/23

Serum Lambda FLC mg/dL (neph)

0.57

2.63

5.21

6.41

4.47

3.88

2.99

4.40

4.07

3.07

3.20

3.27

3.26

Serum Kappa FLC mg/dL (neph)

0.33

1.94

0.13

0.21

0.77

0.90

0.24

0.20

0.17

0.03

0.03

0.16

0.20

Serum K/L Ratio (neph)

0.26

1.65

0.02

0.03

0.17

0.23

0.08

0.04

0.04

0.01

0.01

0.05

0.06

Serum Lambda LC mg/dL (ifix)

325

725

1930

Serum Kappa LC mg/dL (ifix)

625

1360

 101

Serum Kappa/Lambda Ratio (ifix)

1.47

2.95

0.05

Serum IgG mg/dL

700

1700

1260

1277

1302

1437

1305

1508

1706

1715

1511

Serum IgA mg/dL

65

400

21

75

68

80

24

24

34

25

23

Serum IgM mg/dL

60

280

17

< 25

< 25

28

21

26

14

28

20

Bone marrow plasma cells %

0.1

1.5

9.8

8.2

Abnormal cohort in marrow %

0

<1.0

2.0

SPEP Monoclonal Peak g/dL

0

0.52

1.1

1.1

Urine light chains mg/dL

0

0

0

0

0

0

0

0

0

0

0

0

Serum B2M mg/L

0.70

1.80

1.45

1.46

1.48

1.86

CBC PLT platelets K/uL

130

430

189

178

176

181

203

205

187

182

175

165

172

184

166

174

172

CBC WBC white blood count K/uL

3.5

10.8

9.4

5.0

5.0

4.3

4.9

4.7

3.5

9.6

9.3

3.7

5.4

4.6

5.6

5.1

4.4

CBC RBC red blood count M/uL

4.50

5.70

4.64

4.50

4.48

4.53

4.60

4.66

4.60

4.48

4.58

4.76

4.78

4.77

4.78

4.56

4.53

CBC HGB hemoglobin g/dL

13.5

18.0

15.3

14.6

14.5

14.7

15.0

15.5

14.9

14.4

14.9

15.4

15.6

15.6

15.5

14.9

14.7

Chem LDH U/L

100

190

168

167

134

171

152

171

194

166

184

192

192

Chem ALT U/L

30.0

65.0

66.0

67.0

52.0

70.0

73.0

57.0

51.0

43

53

51

58

44

Chem AST U/L